Morphologic study of three cases of insulinoma. Histochemical and ultrastructural studies
Ultrastructural and immunocytochemical features of three human insulinomas, one with metastases and the other two with psammoma bodies and amyloid, respectively, are described. Neoplastic cells of all patients reacted with antihuman insulin antibody using the peroxidase‐antiperoxidase (PAP) method....
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Published in | Cancer Vol. 55; no. 4; pp. 841 - 847 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Wiley Subscription Services, Inc., A Wiley Company
15.02.1985
Wiley-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | Ultrastructural and immunocytochemical features of three human insulinomas, one with metastases and the other two with psammoma bodies and amyloid, respectively, are described. Neoplastic cells of all patients reacted with antihuman insulin antibody using the peroxidase‐antiperoxidase (PAP) method. Ultrastructurally, neoplastic cells consisted of light cells and dark cells, both of which had a large number of secretory granules, microfilaments, ceroid bodies, and phagolysosomes. Psammoma bodies seemed to originate from neoplastic cell debris in one tumor. In another case, amyloid fibrils appeared to be produced by tumor cells, and there was a close association of amyloid with secretory granules. |
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Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 0008-543X 1097-0142 |
DOI: | 10.1002/1097-0142(19850215)55:4<841::AID-CNCR2820550422>3.0.CO;2-Q |