Ritodrine pharmacokinetics

The purpose of this study was to add to the limited information available regarding the pharmacology of ritodrine in the peripartum period when treatment fails and labor is not inhibited. Plasma or urine samples from eight parturients and 13 infants were studied; in addition plasma samples at delive...

Full description

Saved in:
Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 40; no. 6; p. 656
Main Authors Kuhnert, B R, Gross, T L, Kuhnert, P M, Erhard, P, Brashar, W T
Format Journal Article
LanguageEnglish
Published United States 01.12.1986
Subjects
Blood Proteins - metabolism
Chromatography, High Pressure Liquid
Female
Fetal Blood - analysis
Fetus - metabolism
Humans
Infant, Newborn
Kinetics
Maternal-Fetal Exchange
Pregnancy
Ritodrine - blood
Ritodrine - metabolism
Online AccessGet more information

Cover

More Information
Summary:The purpose of this study was to add to the limited information available regarding the pharmacology of ritodrine in the peripartum period when treatment fails and labor is not inhibited. Plasma or urine samples from eight parturients and 13 infants were studied; in addition plasma samples at delivery were obtained from a total of 26 mothers and infants. All the mothers received ritodrine in the 24 hours before delivery. Plasma and urine ritodrine (free and conjugated) were determined with HPLC by electrochemical detection. In maternal plasma, an apparent rapid distribution phase with a t1/2 of 32 +/- 21 minutes was followed by a prolonged equilibrium phase with a t1/2 of 17 +/- 10 hours. Seventy-six percent of the ritodrine excreted by the mother was in the form of a conjugate. Ninety percent of the ritodrine excreted by the neonate was also excreted in the form of a conjugate.
ISSN:0009-9236
DOI:10.1038/clpt.1986.241