Emergent subtype of hepatitis E virus genotype 3 in wild boar in Spain

Wild boar (Sus scrofa) is considered as the main wildlife reservoir of zoonotic hepatitis E virus (HEV) genotypes. The aim of this study was to evaluate the circulation of HEV in free‐ranging wild boar in the Doñana National Park (DNP), Spain. Blood samples were collected from 99 wild boar in the DN...

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Published inTransboundary and emerging diseases Vol. 66; no. 5; pp. 1803 - 1808
Main Authors Caballero‐Gómez, Javier, Jiménez‐Ruiz, Saul, Lopez‐Lopez, Pedro, Vicente, Joaquin, Risalde, Maria A., Cano‐Terriza, David, Frias, Mario, Barasona, Jose A., Rivero, Antonio, García‐Bocanegra, Ignacio, Rivero‐Juarez, Antonio
Format Journal Article
LanguageEnglish
Published Germany Hindawi Limited 01.09.2019
Subjects
Animals
Animals, Wild - virology
Antibodies
Disease Reservoirs - virology
Enzyme-linked immunosorbent assay
Epidemiology
Female
Genotype
genotype 3
Genotypes
Hepatitis
Hepatitis Antibodies - blood
Hepatitis E - epidemiology
Hepatitis E - veterinary
Hepatitis E - virology
hepatitis E virus
Hepatitis E virus - genetics
Humans
Infectivity
Male
National parks
Parks, Recreational
Phylogeny
Public Health
Ribonucleic acid
RNA
Spain - epidemiology
Sus scrofa
Sus scrofa - virology
Viruses
Wildlife
Zoonoses
zoonosis
Spain
hepatitis E virus
genotype 3
zoonosis
public health
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Summary:Wild boar (Sus scrofa) is considered as the main wildlife reservoir of zoonotic hepatitis E virus (HEV) genotypes. The aim of this study was to evaluate the circulation of HEV in free‐ranging wild boar in the Doñana National Park (DNP), Spain. Blood samples were collected from 99 wild boar in the DNP during 2015. Sera were analysed in parallel using indirect ELISA and real‐time RT‐PCR. A total of 57 of the 99 tested animals (57.6%; 95%CI: 47.8%–67.3%) had anti‐HEV antibodies, indicating that this virus is widespread in wild boar in the DNP. HEV RNA was detected in one animal and phylogenetic analysis showed that the sequence isolated belonged to subtype 3r. The results suggest a potential risk of zoonotic transmission of this novel HEV‐3 subtype, which could be of public health concern. Further studies are required to assess the role of wild boar in the epidemiology of HEV‐3r and to determine the infectivity of this emergent HEV subtype in other species, including humans.
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ISSN:1865-1674
1865-1682
DOI:10.1111/tbed.13251