Novel Models of Crohn's Disease Pathogenesis Associated with the Occurrence of Mitochondrial Dysfunction in Intestinal Cells

• Published in: International journal of molecular sciences Vol. 23; no. 9; p. 5141
• Main Authors: Blagov, Alexander, Zhigmitova, Elena B, Sazonova, Margarita A, Mikhaleva, Liudmila M, Kalmykov, Vladislav, Shakhpazyan, Nikolay K, Orekhova, Varvara A, Orekhov, Alexander N
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.05.2022; MDPI
• Subjects: Antibiotics; Antigens; Carbohydrates; Chronic illnesses; Crohn Disease - therapy; Crohn's disease; Crohns disease; Diet; Digestive system; Gene expression; Health risk assessment; Humans; Hypotheses; Industrialized nations; Inflammation; Intestines; Medical research; Microbiota; Mitochondria; mitochondrion; Mutation; Nonsteroidal anti-inflammatory drugs; Nutrition research; Pathogenesis; Permeability; Remission (Medicine); Review; Smoking; Womens health; inflammation; Crohn’s disease; mitochondrion
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23095141

Crohn's disease remains one of the challenging problems of modern medicine, and the development of new and effective and safer treatments against it is a dynamic field of research. To make such developments possible, it is important to understand the pathologic processes underlying the onset and progression of Crohn's disease at the molecular and cellular levels. During the recent years, the involvement of mitochondrial dysfunction and associated chronic inflammation in these processes became evident. In this review, we discuss the published works on pathogenetic models of Crohn's disease. These models make studying the role of mitochondrial dysfunction in the disease pathogenesis possible and advances the development of novel therapies.