Determination of urinary concentrations of pseudoephedrine and cathine after therapeutic administration of pseudoephedrine-containing medications to healthy subjects: implications for doping control analysis of these stimulants banned in sport

Due to its stimulatory effects on the central nervous system, and its structural similarity to banned stimulants such as ephedrine and methamphetamine, pseudoephedrine (PSE) at high doses is considered as an ergogenic aid for boosting athletic performance. However, the status of PSE in the Internati...

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Published inDrug testing and analysis Vol. 4; no. 5; p. 320
Main Authors Barroso, Osquel, Goudreault, Danielle, Carbó Banús, Marcel-lí, Ayotte, Christiane, Mazzoni, Irene, Boghosian, Thierry, Rabin, Olivier
Format Journal Article
LanguageEnglish
Published England 01.05.2012
Subjects
Bronchodilator Agents - administration & dosage
Bronchodilator Agents - metabolism
Bronchodilator Agents - urine
Calibration
Doping in Sports
Drug Administration Schedule
Female
Humans
Male
Phenylpropanolamine - administration & dosage
Phenylpropanolamine - metabolism
Phenylpropanolamine - urine
Pseudoephedrine - administration & dosage
Pseudoephedrine - metabolism
Pseudoephedrine - urine
Substance Abuse Detection
Online AccessGet more information
ISSN1942-7611
DOI10.1002/dta.291

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Summary:Due to its stimulatory effects on the central nervous system, and its structural similarity to banned stimulants such as ephedrine and methamphetamine, pseudoephedrine (PSE) at high doses is considered as an ergogenic aid for boosting athletic performance. However, the status of PSE in the International Standard of the Prohibited List as established under the World Anti-Doping Code has changed over the years, being prohibited until 2003 at a urinary cut-off value of 25 µg/ml, and then subsequently removed from the Prohibited List during the period 2004-2009. The re-consideration of this position by the World Anti-Doping Agency (WADA) List Expert Group has led to the reintroduction of PSE in the Prohibited List in 2010. In this manuscript, we present the results of two WADA-sponsored clinical studies on the urinary excretion of PSE and its metabolite cathine (CATH) following the oral administration of different PSE formulations to healthy individuals at therapeutic regimes. On this basis, the current analytical urinary threshold for the detection of PSE as a doping agent in sport has been conservatively established at 150 µg/ml
ISSN:1942-7611
DOI:10.1002/dta.291