Multivalent, biodegradable polyglycerol hydrogels

In this paper we describe the preparation of disulfide crosslinked polyglycerol hydrogels by the ring-opening crosslinking polymerization of glycerol and polyethylene glycol-based polyepoxides and Na2S2. Multivalent polyglycerol hydrogels were prepared by acid-catalyzed hydrolysis of remaining epoxi...

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Bibliographic Details
Published inInternational journal of artificial organs Vol. 34; no. 2; p. 118
Main Authors Steinhilber, Dirk, Haag, Rainer, Sisson, Adam L
Format Journal Article
LanguageEnglish
Published United States 01.02.2011
Subjects
Absorbable Implants
Cross-Linking Reagents - chemistry
Disulfides - chemical synthesis
Disulfides - chemistry
Fluorescent Dyes - chemistry
Glycerol - chemical synthesis
Glycerol - chemistry
Hydrogels
Hydrogen-Ion Concentration
Hydrolysis
Kinetics
Molecular Structure
Polymers - chemical synthesis
Polymers - chemistry
Solubility
Spectrometry, Fluorescence
Tissue Scaffolds
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Summary:In this paper we describe the preparation of disulfide crosslinked polyglycerol hydrogels by the ring-opening crosslinking polymerization of glycerol and polyethylene glycol-based polyepoxides and Na2S2. Multivalent polyglycerol hydrogels were prepared by acid-catalyzed hydrolysis of remaining epoxide functionalities. Additionally, a near infrared fluorescent dye was encapsulated in the hydrogel network. Our hydrogels show complete degradation in reducing environments and a controlled release of the fluorescence dye was observed. These hydrogels are interesting scaffolds for bioactive substances, which can be released, triggered by the hydrogel degradation.
ISSN:1724-6040
DOI:10.5301/IJAO.2011.6399