Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan

• Published in: International journal of biological macromolecules Vol. 55; pp. 32 - 38
• Main Authors: Hui, Patrick Chi-Leung, Wang, Wen-Yi, Kan, Chi-Wai, Zhou, Chang-E, Ng, Frency Sau-Fun, Wat, Elaine, Zhang, Vanilla Xin, Chan, Chung-Lap, Lau, Clara Bik-San, Leung, Ping-Chung
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2013
• Subjects: agitation; Atopic dermatitis; Capsules - chemistry; chitosan; Chitosan - chemistry; Controlled-release; cortex; Cortex Moutan; crosslinking; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drugs, Chinese Herbal - administration & dosage; Fourier transform infrared spectroscopy; Microencapsulation; Orthogonal array analysis; Paeonia; Particle Size; phosphates; Spectroscopy, Fourier Transform Infrared; Surface Properties; Cortex Moutan; Controlled-release; Microencapsulation; Atopic dermatitis; Orthogonal array analysis
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2012.12.023

► Chitosan microcapsules loaded with Cortex Moutan were prepared and characterised. ► Optimum condition for microcapsule preparation was obtained by orthogonal array analysis. ► The release rate of the microcapsules was good in pH 5.4 of phosphate buffered saline in the first 48h. The process of preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan was studied and the optimum condition for microcapsule preparation was investigated by orthogonal array analysis. Based on the yield percentage of microcapsule, the optimum condition for microcapsule preparation was (i) core–shell ratio=1:2; (ii) chitosan concentration=6% (w/v); (iii) agitation speed=1100rpm; and (iv) cross-linking time=90min. Meanwhile, relative importance of the preparation parameters was in the order: core–shell ratio, agitation speed, chitosan concentration and cross-linking time. The Fourier transform infrared spectroscopy analysis revealed that Cortex Moutan has been completely encapsulated into chitosan microcapsule. The release rate of Cortex Moutan from microcapsules in pH 5.4 phosphate buffered saline (PBS) was slightly better than that in pH 5.0 PBS after the initial 48h and the release rate became steady after that.