Tamoxifen and Partial Oestrogen Agonism in Postmenopausal Women
The effect of tamoxifen on the vaginal mucosa and on serum oestrone, oestradiol and gonadotrophin concentrations was investigated in a group of nine postmenopausal women with non-metastatic breast cancer. Compared with fit age-matched controls, the vaginal pH in the tamoxifen-treated group was signi...
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Published in | Age and ageing Vol. 20; no. 1; pp. 52 - 54 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.01.1991
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
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Summary: | The effect of tamoxifen on the vaginal mucosa and on serum oestrone, oestradiol and gonadotrophin concentrations was investigated in a group of nine postmenopausal women with non-metastatic breast cancer. Compared with fit age-matched controls, the vaginal pH in the tamoxifen-treated group was significantly lower and was comparable to levels in fertile women. Two thirds of tamoxifen-treated women had well oestrogenized vaginal smears compared with none in the control group. Follicle-stimulating hormone was significantly reduced, whilst oestrone and oestradiol levels remained unchanged. We conclude, therefore, that tamoxifen has oestrogen-agonistic properties particularly evident in postmenopausal women, even though it is primarily an antioestrogenic drug. |
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Bibliography: | istex:1ADA3A3E3C2017552CEB8A45573D6BEA2CFAB7B1 ark:/67375/HXZ-96CFLNMW-Z ArticleID:20.1.52 |
ISSN: | 0002-0729 1468-2834 |
DOI: | 10.1093/ageing/20.1.52 |