An experimental model of stress-induced immunosuppression produced by electrical stimulation of the brain in the rat

The present paper reports a model of stress induction, based on electrical stimulation of the brain in normal Wistar rats. Stress-related stimulation of the hypothalamic–pituitary–adrenal axis produced a rise in circulating corticosterone levels that correlated significantly with the impairment of s...

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Bibliographic Details
Published inJournal of neuroimmunology Vol. 114; no. 1; pp. 35 - 39
Main Authors Villaseñor-Garcı́a, Marı́a Martha, Lozoya, Xavier, Puebla-Pérez, Ana Marı́a
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2001
Subjects
Animal models
Animals
Antibodies - blood
Corticosterone - blood
dinitrofluorobenzene
Disease Models, Animal
Electric Stimulation
Erythrocytes - immunology
HPA–axis
Hypersensitivity, Delayed - immunology
Hypothalamo-Hypophyseal System - immunology
Immune Tolerance - immunology
Immunosuppression
Macrophages, Peritoneal - immunology
Male
Phagocytosis - immunology
Rats
Rats, Wistar
Sheep
Stress, Physiological - immunology
HPA–axis
Immunosuppression
Animal models
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Summary:The present paper reports a model of stress induction, based on electrical stimulation of the brain in normal Wistar rats. Stress-related stimulation of the hypothalamic–pituitary–adrenal axis produced a rise in circulating corticosterone levels that correlated significantly with the impairment of some immunological parameters, such as delayed hypersensitivity reactions to dinitrofluorobenzene and to sheep red blood cells, together with changes in splenocyte proliferation and phagocytic activity of peritoneal macrophages. This experimentally elicited stress in the rat is proposed as a suitable model of immunosuppression that could be used for the evaluation of drugs with potential immunomodulatory properties.
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ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(00)00458-6