Erythrocyte and plasma B-6 vitamer concentrations of long-term tobacco smokers, chewers, and nonusers

• Published in: The American journal of clinical nutrition Vol. 62; no. 1; pp. 104 - 109
• Main Authors: Giraud, DW, Martin, HD, Driskell, JA
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1995; American Society for Clinical Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: Adult; Aging - physiology; Biological and medical sciences; Body Height - physiology; Body Weight - physiology; Chromatography, High Pressure Liquid; Eating - physiology; Erythrocytes; Erythrocytes - chemistry; Hematocrit; Humans; Male; Medical sciences; Men; Middle Aged; Plants, Toxic; Pyridoxamine - analogs & derivatives; Pyridoxamine - blood; Pyridoxic Acid - blood; Pyridoxine - administration & dosage; Pyridoxine - blood; Smoking; Smoking - blood; Time Factors; Tobacco; Tobacco, Smokeless; Tobacco, tobacco smoking; Toxicology; Vitamin B; Human; Tobacco; Nutrition; Smoker; Tobacco smoking; B-Vitamins; Pyridoxine; Chewing; Nutritional status
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/62.1.104

Erythrocyte and plasma B-6 vitamer concentrations were determined in males aged 25-55 y who were long-term smokers, chewers, or nonusers. Tobacco users had either smoked (n = 23) or chewed (n = 11) for > 15 y; nonusers (n = 11) had never smoked or chewed. All subjects had normal hematocrit values. Food energy, protein, and vitamin B-6 intakes of the three groups of subjects were not significantly different. All subjects had fasting plasma pyridoxal-5'-phosphate (PLP) concentrations indicative of adequacy. Erythrocyte B-6 vitamer and 4-pyridoxic acid (4-PA) concentrations of all three groups were not significantly different. Nonusers had significantly higher plasma PLP concentrations than did smokers, whereas PLP concentrations of chewers were intermediate between the two groups. Chewers had significantly higher concentrations of plasma pyridoxamine-5'-phosphate (PMP) than other groups. Plasma pyridoxal, pyridoxine, pyridoxamine, and 4-PA concentrations of the three groups were not significantly different. Differences in some B-6 vitamer concentrations in plasma but not in erythrocytes were observed between tobacco users and nonusers.