High thoracic epidural anesthesia does not inhibit Sympathetic nerve activity in the lower extremities

• Published in: Anesthesiology (Philadelphia) Vol. 91; no. 5; pp. 1299 - 1304
• Main Authors: MAGNUSDOTTIR, H, KIRNÖ, K, RICKSTEN, S.-E, ELAM, M
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.11.1999
• Subjects: Anesthesia; Anesthesia, Epidural; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Pressure - drug effects; Electrophysiology; Foot - innervation; Galvanic Skin Response - drug effects; Hand - innervation; Heart Rate - drug effects; Humans; Leg - innervation; Local anesthesia. Pain (treatment); Medical sciences; Muscle, Skeletal - drug effects; Muscle, Skeletal - innervation; Peroneal Nerve - drug effects; Regional Blood Flow - drug effects; Skin - blood supply; Skin - drug effects; Skin - innervation; Skin Temperature - drug effects; Sympathetic Fibers, Postganglionic - drug effects; Sympathetic Nervous System - drug effects; Thoracotomy; Local anesthetic; Human; Regional anesthesia; Bupivacaine; Extradural administration; Blocking; Lower limb; Dorsal spine; Organic amide; Sympathetic nervous system; Anilide
• ISSN: 0003-3022; 1528-1175
• DOI: 10.1097/00000542-199911000-00021

Sympathetic nerve activity was recorded in the leg during high thoracic epidural anesthesia with a segmental sensory blockade of the upper thoracic dermatomes to test the hypothesis that the sympathetic blockade accompanying thoracic epidural anesthesia includes caudal parts of the sympathetic nervous system. Experiments were performed on 10 patients scheduled for thoracotomy. An epidural catheter was inserted at the T3-T4 or T4-T5 interspace. In the main protocol (seven patients), blood pressure, heart rate, and skin temperature (big toe, thumb) were continuously monitored, and multiunit postganglionic sympathetic nerve activity was recorded with a tungsten microelectrode in a muscle-innervating fascicle of the peroneal nerve. After baseline data collection, muscle sympathetic nerve activity was recorded for an additional 45-min period after epidural injection of 4-6 ml bupivacaine, 5 mg/ml. In an additional three patients, the effects of thoracic epidural anesthesia on skin-innervating sympathetic nerve activity were qualitatively assessed. Activation of thoracic epidural anesthesia caused no significant changes in peroneal muscle sympathetic nerve activity (n = 7), blood pressure, or heart rate. Skin temperature increased significantly in the hand 15 min after activation of the blockade, from 32.7 +/- 2.4 degrees C to 34.4 +/- 1.5 degrees C (mean +/- SD), whereas no changes were observed in foot temperature. The sensory blockade extended from T1 (C4-T2) to T8 (T6-T11). A high thoracic epidural anesthesia with adequate sensory blockade of upper thoracic dermatomes may be achieved without blockade of caudal parts of the sympathetic nervous system. This finding differs from that of earlier studies that used indirect methods to evaluate changes in sympathetic nerve activity.