Insight into adenosine receptor function using antisense and gene- knockout approaches

• Published in: Trends in Pharmacological Sciences Vol. 20; no. 2; pp. 79 - 83
• Main Author: Nyce, Jonathan W
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.1999
• Subjects: adenosine receptors; Animals; Antisense oligonucleotides; Baroreflex - drug effects; Baroreflex - physiology; Brain - drug effects; Brain - metabolism; Humans; knock out mice; knockout gene; Lung - drug effects; Lung - metabolism; Mice; Mice, Knockout; Motor Activity - drug effects; Motor Activity - physiology; Oligonucleotides, Antisense - pharmacology; Receptors, Purinergic P1 - drug effects; Receptors, Purinergic P1 - genetics; Receptors, Purinergic P1 - metabolism; Receptors, Purinergic P1 - physiology; Genetics; Antisense oligonucleotides; Pharmacology; adenosine receptors; knock out mice
• ISSN: 0165-6147; 1873-3735
• DOI: 10.1016/S0165-6147(99)01305-X

The extensive role of adenosine in discriminating input from the extracellular environment is effected through a series of cell membrane-spanning proteins – the adenosine A 1, A 2A, A 2B and A 3 receptors. New genetic and epigenetic tools have emerged that facilitate the elucidation of the function of these receptors with greater specificity than is generally possible with traditional antagonist drugs. These tools include antisense oligonucleotides (epigenetic) and gene‘knockin’ and‘knockout’ mice (genetic) and are discussed in this article by Jonathan Nyce.