Genome-wide RNAi

In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of g...

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Bibliographic Details
Published inCurrent Opinion in Chemical Biology Vol. 5; no. 1; pp. 63 - 66
Main Author Barstead, Robert
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2001
Subjects
Animals
C. elegans
Caenorhabditis elegans
Caenorhabditis elegans - genetics
chromosome I
chromosome III
Gene Silencing
Genome
PTGS
RNA, Double-Stranded - genetics
RNA, Double-Stranded - pharmacology
RNAi
gene silencing
RNAi
C. elegans
Genome
PTGS
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Summary:In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematode Caenorhabditis elegans; most of the genes on C. elegans chromosome I and III have now been tested for RNAi phenotypes. The results validate RNAi as a powerful functional genomics tool for C. elegans, and point the way for similar large-scale studies in other species.
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ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(00)00173-3