Effects of radiotherapy on the survival of patients with stage IA and low-grade stage IB uterine endometrioid carcinoma

The present study aimed to evaluate the effects of radiotherapy on the overall survival of patients with primary stage IA, grade I-III uterine endometrioid carcinoma or stage IB, grade I-II uterine endometrioid carcinoma. A total of 7504 patients with stage IA, grade I-III uterine endometrioid carci...

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Bibliographic Details
Published inScientific reports Vol. 13; no. 1; p. 19883
Main Authors Li, Shuqing, Yi, Zhihui, Li, Mingqing, Zhu, Zhiling
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 14.11.2023
Nature Portfolio
Subjects
Cancer
Carcinoma
Carcinoma, Endometrioid - pathology
Endometrial cancer
Endometrial Neoplasms - pathology
Female
Humans
Neoplasm Staging
Proportional Hazards Models
Radiation therapy
Radiotherapy, Adjuvant
Retrospective Studies
Statistical analysis
Survival
Uterus
Uterus - pathology
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Summary:The present study aimed to evaluate the effects of radiotherapy on the overall survival of patients with primary stage IA, grade I-III uterine endometrioid carcinoma or stage IB, grade I-II uterine endometrioid carcinoma. A total of 7504 patients with stage IA, grade I-III uterine endometrioid carcinoma, and 857 patients with stage IB, grade I-II uterine endometrioid carcinoma were collected for the present study. Following propensity score matching (PSM), statistical analysis was performed for the equalized number of patients with stage IA, grade I-III uterine endometrioid carcinoma (n = 383) and patients with stage IB, grade I-II uterine endometrioid carcinoma (n = 330). For patients with primary stage IA, grade I-III uterine endometrioid carcinoma, radiotherapy was found to promoted a reduced 5-year overall survival rates [hazard ratio (HR), 1.726; 95% confidence interval (CI), 1.456-2.046; P < 0.05]. In patients with primary stage IB, grade I-II uterine endometrioid carcinoma, no significant differences were observed in the 5-year overall survival rates between radiotherapy and no radiotherapy groups (P = 0.059). In conclusion, radiotherapy may not improve 5-year overall survival for patients with primary stage IA, grade I-III or stage IB, grade I-II uterine endometrioid carcinoma.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-46435-y