Two New Benzofulvene Sesquiterpenoids from the Stems of Nicotiana tabacum and their Antibacterial Activity

Two new benzofulvene sesquiterpenoids, tabanoids A and B ( 1 and 2 ) as well as five known sesquiterpenoids ( 3–7 ) were isolated from the stem of Nicotiana tabacum . Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 wer...

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Published inChemistry of natural compounds Vol. 59; no. 6; pp. 1092 - 1096
Main Authors Shang, Shan-Zhai, Dai, Jia-Meng, Xiong, Wen, Wang, Hui-Ping, Zhao, Wei, Qin, Shi-Chun, Li, Yong, Cai, Hao-Cheng, Wang, Wei-Guang, Hu, Qiu-Fen, Cai, Jie-Yun
Format Journal Article
LanguageEnglish
Published New York Springer US 01.11.2023
Springer Nature
Springer
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Medicinal
Chemistry, Organic
Chemistry/Food Science
Life Sciences & Biomedicine
Methicillin
NMR
Nuclear magnetic resonance
Organic Chemistry
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
Science & Technology
Sesquiterpenes
antibacterial activity
sesquiterpenoids
Nicotiana tabacum
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Summary:Two new benzofulvene sesquiterpenoids, tabanoids A and B ( 1 and 2 ) as well as five known sesquiterpenoids ( 3–7 ) were isolated from the stem of Nicotiana tabacum . Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD of 15.2 ± 2.5, and 12.8 ± 2.2 mm, respectively.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-04203-4