Ricin

The plant toxin ricin consists of two disulfide-linked polypeptides with different functions. The A-chain enters the cytosol and inactivates the ribosomes enzymatically, whereas the B-chain has lectin properties and binds to carbohydrates at the cell surface. This binding is a requirement for transl...

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Bibliographic Details
Published inToxicon (Oxford) Vol. 39; no. 11; pp. 1723 - 1728
Main Authors Olsnes, Sjur, Kozlov, Jurij V.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2001
Subjects
Animals
Biological Transport
Cytosol - metabolism
Endocytosis
Humans
Immunotoxin
Lectin
Models, Molecular
Ricin
Ricin - chemistry
Ricin - metabolism
Ricin - toxicity
Toxin
Translocation
Translocation
Toxin
Lectin
Endocytosis
Immunotoxin
Ricin
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Summary:The plant toxin ricin consists of two disulfide-linked polypeptides with different functions. The A-chain enters the cytosol and inactivates the ribosomes enzymatically, whereas the B-chain has lectin properties and binds to carbohydrates at the cell surface. This binding is a requirement for translocation of the A-chain to the cytosol. The bound toxin is endocytosed and transported retrograde through the Golgi apparatus to the endoplasmic reticulum where it appears to be translocated to the cytosol by the sec61p complex.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(01)00158-1