Cholecystokinin modulation of apomorphine- or amphetamine-induced stereotypy in rats: opposite effects

• Published in: Peptides (New York, N.Y. : 1980) Vol. 22; no. 8; pp. 1291 - 1298
• Main Authors: Tieppo, Carla A., Felicio, Luciano F., Nasello, Antonia G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2001
• Subjects: Amphetamines - pharmacology; Animals; Apomorphine - pharmacology; CCK A; CCK B; CCK4; CCK8; Cholecystokinin - pharmacology; Dopamine; Dopamine - metabolism; Dopamine Agonists - pharmacology; Drug Interactions; Male; Rats; Rats, Wistar; Receptors, Cholecystokinin - metabolism; Sincalide - pharmacology; Stereotyped behavior; Synapses - drug effects; Tetragastrin - pharmacology; Time Factors; CCK8; CCK B; CCK A; Dopamine; Stereotyped behavior; CCK4
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/S0196-9781(01)00454-5

Stereotyped behavior can be induced by the dopamine agonist apomorphine or by the releasing agent amphetamine. Cholecystokinin influence on dopamine-mediated behaviors has been extensively studied but a real controversy remains. Our purpose was to further characterize the dopamine-cholecystokinin interaction in apomorphine- and amphetamine-induced stereotyped behavior using sulphated cholecystokinin octapeptide (CCK8) and cholecystokinin tetrapeptide (CCK4) treatments. The results showed that CCK8 decreases apomorphine-induced stereotyped behavior and CCK4 has no effect. CCK4 and CCK8 increased the amphetamine-induced stereotyped behavior; CCK4 was more effective. The results confirm the opposite modulation of apomorphine or amphetamine-induced stereotyped behavior by CCK. These data suggest that this modulation is mediated by both CCK receptors on apomorphine-induced and only by CCK 2 receptors on amphetamine-induced stereotyped behavior.