Synergistic Interactions of Phytochemicals in Polyherbal Formulation Enhance the Chemical Transformations of Active Constituents

Synergetic chemical interaction of various phytochemicals in Amruthotharam kashayam, a polyherbal formulation, has been evaluated by different spectroscopic techniques. Comparative chemical profiling was done along with its ingredient plants by HPTLC analysis. Characterization of major chemical cons...

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Published inJournal of applied spectroscopy Vol. 88; no. 1; pp. 181 - 186
Main Authors Sulaiman, C. T., Anju, K., Anandan, E. M., Balachandran, I.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2021
Springer
Springer Nature B.V
Subjects
Analysis
Analytical Chemistry
Atomic/Molecular Structure and Spectra
Biological products
Chemical reactions
Constituents
Fourier transforms
Infrared analysis
Infrared spectroscopy
Physics
Physics and Astronomy
Phytochemicals
Spectrophotometry
Amruthotharam kashayam
tandem mass spectroscopic analyses
chemical transformation
Fourier transform infra-red spectroscopy
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Summary:Synergetic chemical interaction of various phytochemicals in Amruthotharam kashayam, a polyherbal formulation, has been evaluated by different spectroscopic techniques. Comparative chemical profiling was done along with its ingredient plants by HPTLC analysis. Characterization of major chemical constituents was carried out by Fourier transform infrared spectroscopy (FTIR) and tandem mass spectroscopic analyses (LC/MS-MS). The chromatographic profiling and spectrophotometric studies revealed that the chemistry of the finished formulation is different from that of individual plant extracts. FTIR analysis showed the spectral shift in the formulation when compared with corresponding transmittance in the ingredient plants. The synergetic chemical reaction during the process is evidenced by such specific spectral shift. The tandem mass spectroscopic studies also confirmed the chemical transformations happening during the preparation of Amruthotharam kashayam.
ISSN:0021-9037
1573-8647
DOI:10.1007/s10812-021-01156-w