Expression systems for use in actinomycetes and related organisms

There have been significant advances in genetic and molecular approaches to understanding the physiology of organisms belonging to the genera Mycobacterium, Corynebacterium, Nocardia and Streptomyces. This review discusses recent advances in heterologous protein expression in members of the actinomy...

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Bibliographic Details
Published inCurrent Opinion in Biotechnology Vol. 12; no. 5; pp. 446 - 449
Main Author Connell, Nancy D
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2001
Subjects
Actinomycetales - genetics
Actinomycetales - metabolism
actinomycetes
Bacterial Proteins - analysis
Bacteriophages - genetics
Corynebacterium
Corynebacterium - genetics
Gene Expression Regulation, Bacterial
mycobacteria
Mycobacterium
Mycobacterium - genetics
Nocardia
Nocardia - genetics
Plasmids
Promoter Regions, Genetic
protein expression
Protein Processing, Post-Translational
Recombinant Proteins - analysis
Recombinant Proteins - biosynthesis
secondary metabolites
Streptomyces
Streptomyces - genetics
Transcriptional Activation
Biotechnology
Boichemistry
secondary metabolites
Microbiology
actinomycetes
protein expression
mycobacteria
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Summary:There have been significant advances in genetic and molecular approaches to understanding the physiology of organisms belonging to the genera Mycobacterium, Corynebacterium, Nocardia and Streptomyces. This review discusses recent advances in heterologous protein expression in members of the actinomycete group, including codon usage, post-translational modification and inducible gene expression.
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ISSN:0958-1669
1879-0429
DOI:10.1016/S0958-1669(00)00243-3