Is neutrophil to lymphocyte ratio a predictive factor for recurrence of urethral stricture?

• Published in: Revista da Associacao Medica Brasileira (1992) Vol. 65; no. 12; pp. 1448 - 1453
• Main Authors: Urkmez, Ahmet, Topaktas, Ramazan, Ozsoy, Emrah, Tokuc, Emre, Kutluhan, Musab Ali, Artuk, Ilker, Kayar, Ridvan, Ozturk, Metin Ishak
• Format: Magazine Article
• Language: English
• Published: Brazil 01.12.2019
• Subjects: Adult; Aged; Follow-Up Studies; Humans; Lymphocyte Count - methods; Middle Aged; Neutrophils; Recurrence; Retrospective Studies; ROC Curve; Statistics, Nonparametric; Time Factors; Treatment Outcome; Urethra - surgery; Urethral Stricture - blood; Urethral Stricture - surgery; Young Adult
• ISSN: 0104-4230; 1806-9282
• DOI: 10.1590/1806-9282.65.12.1448

Due to spongiofibrosis and inflammatory processes underlying the pathogenesis of urethral stricture, it is possible that the neutrophil-lymphocyte ratio (NLR) may give essential information about the course of the disease and recurrence possibilities. Our study aims to evaluate the correlation between NLR and recurrence rates. A total of 512 patients who underwent direct visual internal urethrotomy (DVIU) due to urethral stricture in our clinic between February 2010 and January 2018 were evaluated retrospectively. The median follow up for non-recurrent and recurrent groups after DVIU was 30 and 36 months, respectively. During the follow-up, 280 (54.7%) of the patients had recurrences, and 232 (45,3%) had no recurrences. The mean time for recurrence after DVIU was 6,5±1,4 months, with a range of 1-36 months. The mean NLR in the non-recurrence group was 2,02±0,87, with a median of 1.9, and 3,66±2,30, with a median of 3 in the recurrence group. A highly significant statistical difference was observed between two groups in terms of neutrophil count and NLR (p: 0.000 - both). The area under curve value for NLR was 0.767, with a standard error of 0.021 (95% CI 0.727-0.808). The cut-off value of NLR was determined as 2.25, with a 70% sensitivity and 67,7% specificity. By using NLR, the inflammatory features of the urethral tissue can be predicted, and possible recurrences after surgery can be estimated. Consequently, open urethroplasty techniques can be used in cases with a significant NLR value instead of the recurrent endoscopic procedure.