Functional materials for microscale genomic and proteomic analyses

• Published in: Current Opinion in Biotechnology Vol. 13; no. 2; pp. 87 - 94
• Main Authors: Vreeland, Wyatt N, Barron, Annelise E
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2002
• Subjects: Acrylamides - chemistry; Adsorption; bioconjugate; bioseparation; Coated Materials, Biocompatible; DNA - analysis; Electrochemistry; Electrophoresis, Capillary - instrumentation; Electrophoresis, Capillary - methods; genomics; Human Genome Project; Humans; microchannel; microscale systems; Miniaturization - instrumentation; Miniaturization - methods; Models, Molecular; Oligonucleotide Array Sequence Analysis - methods; Osmosis; Povidone - chemistry; Proteome - analysis; proteomics; Sequence Analysis, DNA - instrumentation; Sequence Analysis, DNA - methods; Sequence Analysis, Protein - instrumentation; Sequence Analysis, Protein - methods; Surface Properties; bioconjugate; microscale systems; microchannel; Biotechnology; proteomics; Techniques & Methods; genomics; Biochemistry; bioseparation
• ISSN: 0958-1669; 1879-0429
• DOI: 10.1016/S0958-1669(02)00292-6

The design of functional materials for genomic and proteomic analyses in microscale systems has begun to mature, from materials designed for capillary-based electrophoresis systems to those tailored for microfluidic-based or ‘chip-based’ platforms. In particular, recent research has focused on evaluating different polymer chemistries for microchannel surface passivation and improved DNA separation matrix performance. Additionally, novel bioconjugate materials designed specifically for electrophoretic separations in microscale channels are facilitating new separation modalities. The design of functional materials for genomic and proteomic analyses in microscale systems has begun to mature, from materials designed for capillary-based electrophoresis systems to those tailored for microfluidic-based or ‘chip-based’ platforms.