Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours

• Published in: British journal of psychiatry Vol. 220; no. 2; pp. 76 - 78
• Main Authors: Chye, Yann, Suo, Chao, Romero-Garcia, Rafael, Bethlehem, Richard A.I., Hook, Roxanne, Tiego, Jeggan, Goodyer, Ian, Jones, Peter B., Dolan, Ray, Bullmore, Edward T., Grant, Jon E., Yücel, Murat, Chamberlain, Samuel R.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2022
• Subjects: Behavior; Behavior problems; Brain; Brain research; Compulsions; Disinhibition; Frontal gyrus; Functional connectivity; Impulsivity; Magnetic resonance imaging; Mental disorders; Nervous system; Neural networks; Neuropsychiatry; Neurosciences; Obsessive compulsive disorder; Phenotypes; Phenotyping; Psychiatry; Short report; Software packages; Time series; United Kingdom > UK; connectome; Impulsivity; compulsivity; transdiagnostic; brain network
• ISSN: 0007-1250; 1472-1465
• DOI: 10.1192/bjp.2021.49

Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic ‘disinhibition’ phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.