Left ventricular response to experimentally induced chronic aortic regurgitation

Left ventricular characteristics in 13 dogs with aortic regurgitation of 36 to 468 days duration were compared with those of 15 normal dogs. The test group exhibited significant chronic dilatation and hypertrophy and elevated left ventricular end-diastolic pressure, but contractility (tension—veloci...

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Published inCardiovascular research Vol. 6; no. 4; pp. 404 - 414
Main Authors TAYLOR, ROGER R., HOPKINS, BARRY E., BURROWS, PETER
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.07.1972
Subjects
Animals
Aortic Valve Insufficiency - physiopathology
Blood Pressure
Body Weight
Cardiac Output
Cardiomegaly - etiology
Dogs
Heart - physiopathology
Heart Rate
Heart Ventricles - anatomy & histology
Heart Ventricles - physiopathology
Muscle Contraction
Organ Size
Stress, Mechanical
Time Factors
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Summary:Left ventricular characteristics in 13 dogs with aortic regurgitation of 36 to 468 days duration were compared with those of 15 normal dogs. The test group exhibited significant chronic dilatation and hypertrophy and elevated left ventricular end-diastolic pressure, but contractility (tension—velocity relations) was normal in the group as a whole. In animals with the more severe and prolonged duration of lesions, however, contractility was depressed, although this was not reflected in greater elevation of left ventricular end-diastolic pressure.
Bibliography:istex:FC85C27D4663CF29B9DB05F1F4600FF3EC7F5E12
ark:/67375/HXZ-6HWCG2R7-B
ArticleID:6-4-404
1 This investigation was supported by the Noel Beaven Heart Foundation of Western Australia and a grant (G668 594) from the National Heart Foundation of Australia.
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ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/6.4.404