CT-Derived Body Composition Values and Complications After Pneumonectomy in Lung Cancer Patients: Time for a Sex-Related Analysis?

• Published in: Frontiers in oncology Vol. 12; p. 826058
• Main Authors: Rizzo, Stefania, Petrella, Francesco, Bardoni, Claudia, Bramati, Lorenzo, Cara, Andrea, Mohamed, Shehab, Radice, Davide, Raia, Giorgio, Del Grande, Filippo, Spaggiari, Lorenzo
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.03.2022
• Subjects: body composition; complications; fat; lung cancer; muscle; Oncology; sex; lung cancer; body composition; complications; muscle; sex; fat; pneumonectomy
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2022.826058

This study aimed to assess if CT-derived body composition values and clinical characteristics are associated with the risk of postsurgical complications in men and women who underwent pneumonectomy for lung cancer. Patients who underwent pneumonectomy between 2004 and 2008 were selected. The ethics committee approved this retrospective study with waiver of informed content. Main clinical data collected were sex, age, weight and height to calculate body mass index (BMI), albumin, C-reactive protein, smoking status, side, sarcopenia, presurgical treatments, reoperation, and complications within 30 days after pneumonectomy, classified as: lung complications, cardiac complications, other complications, and any complication. From an axial CT image at the level of L3, automatic segmentations were performed to calculate skeletal muscle area (SMA), skeletal muscle density, subcutaneous adipose tissue, and visceral adipose tissue. Skeletal muscle index was calculated as SMA/square height. Univariate and multivariate logistic regression analyses were performed to estimate the risk of any complication, both on the total population and in a by sex subgroup analysis. All tests were two tailed and considered significant at 5% level. A total of 107 patients (84 men and 23 women) were included. Despite no significant differences in BMI, there were significant differences of body composition values in muscle and adipose tissue parameters between men and women, with women being significantly more sarcopenic than men (  = 0.002). Separate analyses for men and women showed that age and SMA were significantly associated with postoperative complications in men (  = 0.03 and 0.02, respectively). Body composition measurements extracted from routine CT may help in predicting complications after pneumonectomy, with men and women being different in quantity and distribution of muscle and fat, and men significantly more prone to postpneumonectomy complications with the increase of age and the decrease of skeletal muscle area.