Changes of cell-vascular complex in zones of adaptive remodeling of the bone tissue under microgravity conditions

• Published in: Advances in space research Vol. 32; no. 8; pp. 1477 - 1481
• Main Authors: Rodionova, N.V., Oganov, V.S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2003
• Subjects: Alkaline Phosphatase - metabolism; Animals; Bone Development - physiology; Bone Remodeling - physiology; Cell Differentiation - physiology; Epiphyses; Femur - blood supply; Femur - cytology; Femur - ultrastructure; Microscopy, Electron; Osteoblasts - cytology; Osteoblasts - ultrastructure; Osteogenesis - physiology; Periosteum - ultrastructure; Rats; Space Flight; Weightlessness
• ISSN: 0273-1177; 1879-1948
• DOI: 10.1016/S0273-1177(03)90384-X

We examined the peculiarities of the structure of the blood-vascular bed and perivascular cells in zones of osteogenesis in the epiphyses and metaphises of femoral bones of rats, flown aboard the US laboratory SLS-2 for two weeks by electron microscopy and histochemistry. In zones of bone remodeling, there was a tendency for a reduction of sinusoid capillary specific volume. Endotheliocytes preserve the typical structure. In the population of perivascular cells, we discovered differentiating osteogenic cells that contained alkaline phosphomonoesterase as well as cells that don't contain this enzyme and differentiate into fibroblasts. The fibroblasts genesis in zones of adaptive remodeling of spongy bones leads to a further development of fibrous tissue that is not subject to mineralization.