Accelerating the discovery of biocompatible ionic liquids

High throughput screening is the first stage of determining the ecotoxicity of ionic liquids. The available methods are reviewed, and a critical analysis of the problems and pitfalls is presented. A critical assessment of high throughput screens for ionic liquid toxicity.

Saved in:
Bibliographic Details
Published inPhysical chemistry chemical physics : PCCP Vol. 12; no. 8; pp. 167 - 1674
Main Authors Wood, Nicola, Stephens, Gill
Format Journal Article
LanguageEnglish
Published England 01.01.2010
Subjects
High-Throughput Screening Assays
Immunodiffusion
Ionic Liquids - chemistry
Ionic Liquids - toxicity
Toxicity Tests
Online AccessGet full text

Cover

More Information
Summary:High throughput screening is the first stage of determining the ecotoxicity of ionic liquids. The available methods are reviewed, and a critical analysis of the problems and pitfalls is presented. A critical assessment of high throughput screens for ionic liquid toxicity.
Bibliography:Gill Stephens is an interdisciplinary bioscientist, with a BSc in Biochemistry from Kent and a PhD from Warwick. In 1988, she moved to a lectureship in Chemical Engineering, UMIST (now University of Manchester), and she will move to a chair in Bioprocessing at the University of Nottingham in March 2010. Gill's group works on biocatalytic production of chemicals, especially from renewable feedstocks. In this context, ionic liquids often outperform conventional solvents for delivery of water-insoluble and/or toxic substrates, hence our interest in their biocompatibility.
Nicola Wood is a PhD student in the final year of her PhD program at the University of Manchester with Prof. Roy Goodacre and Dr Gill Stephens. Her research is focused on toxicity screening of ionic liquids using micro-organisms. Her research is funded by the BBSRC. She previously obtained a BSc qualification in Forensic Science from Anglia Ruskin University and an MSc qualification in Physical Methods of Bioanalysis and Post Genome Science from the University of Manchester.
ISSN:1463-9076
1463-9084
DOI:10.1039/b923429b