Free radical-induced double lesions in DNA

• Published in: Free Radical Biology and Medicine Vol. 31; no. 7; pp. 856 - 868
• Main Authors: Box, Harold C, Dawidzik, Jean B, Budzinski, Edwin E
• Format: Book Review Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2001
• Subjects: Animals; DNA - drug effects; DNA - metabolism; DNA damage; DNA Damage - drug effects; DNA Damage - physiology; DNA repair; Double lesions; Fenton chemistry; Free radical-induced DNA damage; Free radicals; Free Radicals - metabolism; Free Radicals - pharmacology; guanine; Guanine - metabolism; Humans; Oligodeoxyribonucleotides - metabolism; Oxygen - metabolism; Radiation-induced DNA damage; Reactive oxygen species (ROS); Reactive Oxygen Species - metabolism; Reactive Oxygen Species - pharmacology; Tandem lesions; Vicinal lesions; Double lesions; Free radicals; Fenton chemistry; Radiation-induced DNA damage; Vicinal lesions; DNA damage; Reactive oxygen species (ROS); Tandem lesions; DNA repair; Free radical-induced DNA damage
• ISSN: 0891-5849; 1873-4596
• DOI: 10.1016/S0891-5849(01)00653-0

This review surveys the work that has been done on free radical-induced DNA double lesions. Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participation of guanine. The identification of double lesions in oligomer and polymer DNA is reviewed and possible mechanisms of formation are outlined. The potential biological significance of double lesions is discussed. Double lesions induced by UV light are outside the scope of this review.