Prenatal morphine exposure alters estrogen regulation of κ receptors in the cortex and POA of adult female rats but has no effects on these receptors in adult male rats

• Published in: Brain research Vol. 894; no. 1; pp. 154 - 156
• Main Authors: Rimanóczy, Ágnes, Šlamberová, Romana, Vathy, Ilona
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 09.03.2001
• Subjects: Analgesics, Opioid - pharmacology; Animals; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Estradiol; Estrogens - metabolism; Female; Male; Morphine - pharmacology; Ovariectomy; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal morphine; Preoptic Area - drug effects; Preoptic Area - metabolism; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa - drug effects; Receptors, Opioid, kappa - metabolism; Sex Factors; κ Opioid receptors; κ Opioid receptors; Prenatal morphine; Neurotransmitters, modulators, transporters, and receptors; Estradiol
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(00)03326-6

The binding characteristics of κ receptors were assessed in the frontal cortex (CX), striatum, hypothalamus, preoptic area (POA), cerebellum, and ventral tegmental area of adult male and female rats exposed prenatally to morphine or saline. Prenatal morphine exposure altered estrogen regulation of κ receptors in the CX and POA of females, but had no effects on κ receptors in any of the examined brain regions in male rats.