Ocular Adverse Effects in Atopic Dermatitis Patients Treated With Dupilumab: A Bibliometric Analysis
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin disorders. Dupilumab, the first targeted biological drug approved for the treatment of AD, has been widely used, along with increasing ocular adverse effects (AEs). To perform a bibliometric analysis of all the qualified lite...
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Published in | Frontiers in medicine Vol. 9; p. 802036 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
03.03.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Atopic dermatitis (AD) is one of the most common chronic inflammatory skin disorders. Dupilumab, the first targeted biological drug approved for the treatment of AD, has been widely used, along with increasing ocular adverse effects (AEs).
To perform a bibliometric analysis of all the qualified literature involving ocular AEs during the treatment of AD with dupilumab.
Relevant studies were extracted from the Web of Science database and screened by researchers. The bibliographic analysis was performed using the VOSviewer.
A total of 138 articles were enrolled in this study. The first study was published in 2016 by Oregon Health and Science University from the United States. The majority of publications were published in the past 3 years.
published the highest number of articles. The United States was the country with the most publications. Sanofi (France) and Regeneron Pharmaceuticals (USA) were the leading organizations with the most contributions. Conjunctivitis was the most common ocular AE. The management of AD will continue to be the research hotspot and development trend in this area. The milestone research is the first article "Two Phase 3 Trials of Dupilumab vs. Placebo in Atopic Dermatitis" published in the
. Most of the top 10 papers were mainly randomized, placebo-controlled phase 2 and phase 3 clinical trials and real-life large cohort studies.
This study may help better understand ocular AEs in the dupilumab treatment of AD, and grasp the research trends and most influential topics in this field. |
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Bibliography: | content type line 23 SourceType-Scholarly Journals-1 Edited by: Paolo Fogagnolo, University of Milan, Italy This article was submitted to Ophthalmology, a section of the journal Frontiers in Medicine Reviewed by: Serena Lembo, University of Salerno, Italy; Alvise Sernicola, University of Padua, Italy |
ISSN: | 2296-858X 2296-858X |
DOI: | 10.3389/fmed.2022.802036 |