Localization of angiotensin II (AT 1)-receptor-immunoreactive fibres in the hypothalamus of rats: angiotensin II-sensitive tanycytes in the ependyma of the third ventricle?

Scanning the hypothalamus of rats for receptor binding sites of the octapeptide hormone angiotensin II (ANG II), we observed ANG II-sensitive fibres in the ventrolateral hypothalamus. The ANG II (AT 1)-receptor-immunoreactive processes originate from cells—probably tanycytes—embedded in the base and...

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Published inBrain research Vol. 967; no. 1; pp. 281 - 284
Main Authors Thomas, Martin Alexander, Hauptfleisch, Stefan, Fleissner, Gerta, Lemmer, Björn
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 28.03.2003
Subjects
Angiotensin II
Angiotensin II (AT 1)-receptor
Angiotensin II - analysis
Animals
Ependyma
Ependyma - chemistry
Hypothalamus
Hypothalamus - chemistry
Immunochemistry
Male
Nerve Fibers - chemistry
Rat
Rats
Rats, Sprague-Dawley
Receptor, Angiotensin, Type 1
Receptors, Angiotensin - analysis
Tanycyte
Third Ventricle - chemistry
Tanycyte
Rat
Angiotensin II (AT 1)-receptor
Hypothalamus
Staining, tracing and imaging techniques
Angiotensin II
Ependyma
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Summary:Scanning the hypothalamus of rats for receptor binding sites of the octapeptide hormone angiotensin II (ANG II), we observed ANG II-sensitive fibres in the ventrolateral hypothalamus. The ANG II (AT 1)-receptor-immunoreactive processes originate from cells—probably tanycytes—embedded in the base and the ventrolateral walls of the third ventricle and reach into the retrochiasmatic area, the ventrolateral hypothalamus and the median eminence.
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ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(02)04242-7