Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China

• Published in: Genetics and molecular research Vol. 9; no. 2; pp. 765 - 771
• Main Authors: Yang, L, Shi, G L, Song, C X, Xu, S F
• Format: Journal Article
• Language: English
• Published: Brazil 01.01.2010
• Subjects: Adult; Aged; Alleles; Asian Continental Ancestry Group - genetics; Carcinoma, Non-Small-Cell Lung - genetics; Case-Control Studies; Chemokine CCL2 - genetics; China; Ethnic Groups - genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Smoking - genetics; China
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/vol9-2gmr740

Monocyte chemoattractant protein 1 (MCP-1) is an important chemokine that has a dose-dependent anti-tumoral effect. Polymorphism in the MCP-1 distal regulatory region (-2518A/G) can affect the level of MCP-1 expression. We examined the polymorphisms of 112 unrelated patients with non-small-cell lung cancer (NSCLC) and 82 unrelated healthy controls of Han nationality in North China using PCR-RFLP. We found that the distributions of AA, AG and GG genotypes of MCP-1-2518 were significantly different in NSCLC patients compared to controls (chi(2) = 10.106, P = 0.006). There was a significant increase in the frequency of the AA genotype (odds ratio (OR) = 3.138, chi(2) = 8.905, P = 0.003) and a significant decrease in the frequency of the GG genotype (OR = 0.516, chi(2) = 4.613, P = 0.032) in the NSCLC patients, compared to controls. The frequencies of AA, AG and GG genotypes did not differ in the NSCLC patients according to the number of pack-years smoked. Based on these results, we suggest that the MCP-1 -2518A/G polymorphism is associated with genetic susceptibility to NSCLC.