Polycaprolactone-b-poly(N-isopropylacrylamide) nanoparticles: Synthesis and temperature induced coacervation behavior
[Display omitted] •PCL-b-PNIPAM block copolymers were synthesized by TAD-diene click chemistry.•The block copolymers self-assembled in water, forming colloidal nanoparticles.•Temperature responsive coacervation of the colloidal nanoparticles was observed. Poly(caprolactone)-b-poly(N-isopropylacrylam...
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Published in | European polymer journal Vol. 98; pp. 468 - 474 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.01.2018
Elsevier BV |
Subjects | |
Online Access | Get full text |
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Summary: | [Display omitted]
•PCL-b-PNIPAM block copolymers were synthesized by TAD-diene click chemistry.•The block copolymers self-assembled in water, forming colloidal nanoparticles.•Temperature responsive coacervation of the colloidal nanoparticles was observed.
Poly(caprolactone)-b-poly(N-isopropylacrylamide) (PCL-b-PNIPAM) copolymers were prepared with different compositions of the individual blocks using a combination of enzyme catalyzed anionic ring opening (AROP) polymerization, reversible addition fragmentation chain transfer (RAFT) polymerization and triazolinedione-diene click chemistry. Study of the self-assembly of these block copolymers at different temperatures demonstrates the formation of nanoparticles, characterized by a thermo-responsive behavior that is strongly dependent on the PNIPAM block length. At elevated temperature, self-aggregation (coacervation) of the nanoparticles could occur, leading to the formation of larger polymer aggregates. |
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ISSN: | 0014-3057 1873-1945 |
DOI: | 10.1016/j.eurpolymj.2017.11.027 |