Letter to the Editor concerning “Management of cranial chondroblastoma in adults; a pooled analysis” by Amr Muhammed et al

• Published in: American journal of otolaryngology Vol. 42; no. 1; p. 102756
• Main Authors: Zheng, Bo-Wen, Niu, Hua-Qing, Wang, Xiao-Bin, Li, Jing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; Elsevier Limited
• Subjects: Adult; Bone Neoplasms; Calcification; Cartilage; Chondroblastoma; Chondroblastoma - diagnosis; Chondroblastoma - surgery; Fibroblasts; Humans; Medical prognosis; Patients; Radiation therapy; Senescence; Skull; Spinal Fusion; Stem cells; Tumors
• ISSN: 0196-0709; 1532-818X; 1532-818X
• DOI: 10.1016/j.amjoto.2020.102756

[...]the authors divided the study subjects into two groups based solely on the presence of tumor remnants, ignoring the impact of the surgical resection method on the patients. [...]some studies have also pointed out that radiotherapy may cause malignant sarcomatoid changes in tumors [16]. [...]It has been found that radiotherapy can induce senescence-like changes in tumor-associated fibroblasts, which can maintain the activation of the tumor microenvironment and promote tumor progression [17]; Additionally, another study pointed out that radiotherapy can induce the emergence of new stem cells in malignant tumor tissues [18,19]. Regrettably, most of the included studies did not provide detailed radiotherapy information about patients, which may affect the evaluation of the true effect of radiotherapy on patient clinical outcomes. [...]future studies with large samples and well-documented radiotherapy information are needed to further evaluate the impact of adjuvant radiotherapy on the prognosis of patients with cranial CB.