Fighting against Skin Aging The Way from Bench to Bedside

As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied...

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Bibliographic Details
Published inCell transplantation Vol. 27; no. 5; pp. 729 - 738
Main Authors Zhang, Shoubing, Duan, Enkui
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.05.2018
Subjects
Humans
Inflammation - pathology
Models, Biological
Reviews
Skin Aging - genetics
Skin Aging - physiology
Stem Cell Transplantation
Telomere - metabolism
Translational Research, Biomedical
extrinsic aging
skin aging
treatment strategy
extracellular matrix
intrinsic aging
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Summary:As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. In this review, we summarize these changes in skin aging, research advances of the molecular mechanisms leading to these changes, and the treatment strategies aimed at preventing or reversing skin aging.
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ISSN:0963-6897
1555-3892
1555-3892
DOI:10.1177/0963689717725755