Axis formation and patterning in zebrafish

A large collection of mutations affecting zebrafish embryogenesis was described in 1996. The cloning of the affected genes has now provided novel insights into the role and regulation of signaling by BMP, Nodal, Wnt, FGF, Hedgehog, Delta, Slit, retinoic acid and lipids. Detailed analyses have reveal...

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Bibliographic Details
Published inCurrent Opinion in Genetics & Development Vol. 11; no. 4; pp. 393 - 404
Main Author Schier, Alexander F
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2001
Subjects
Animals
axis formation
Axis, Cervical Vertebra - embryology
Body Patterning - physiology
cloning
Endoderm - physiology
Mesoderm - physiology
patterning
signaling
zebrafish
Zebrafish - embryology
signaling
axis formation
Cell biology
Development
Genetics
zebrafish
patterning
cloning
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Summary:A large collection of mutations affecting zebrafish embryogenesis was described in 1996. The cloning of the affected genes has now provided novel insights into the role and regulation of signaling by BMP, Nodal, Wnt, FGF, Hedgehog, Delta, Slit, retinoic acid and lipids. Detailed analyses have revealed a complex genetic network that patterns the early embryo.
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ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00209-4