Structurally Analogous Proteins Do Exist

The structure of a random protein sequence selected in vitro for ATP binding (Lo Surdo et al., 2004) resembles the treble clef zinc binding motif. Since this artificial protein does not share a common ancestor with any natural treble clefs, it exemplifies the existence of structural analogs.

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Bibliographic Details
Published inStructure Vol. 12; no. 7; pp. 1125 - 1127
Main Authors Krishna, S.Sri, Grishin, Nick V
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2004
Subjects
Adenosine Triphosphate - chemistry
Adenosine Triphosphate - metabolism
Carrier Proteins - chemistry
Carrier Proteins - metabolism
Models, Molecular
Protein Binding
Protein Folding
Protein Structure, Secondary
Recombinant Fusion Proteins - chemistry
Recombinant Fusion Proteins - metabolism
Structural Homology, Protein
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Summary:The structure of a random protein sequence selected in vitro for ATP binding (Lo Surdo et al., 2004) resembles the treble clef zinc binding motif. Since this artificial protein does not share a common ancestor with any natural treble clefs, it exemplifies the existence of structural analogs.
Bibliography:SourceType-Other Sources-1
ObjectType-News-1
content type line 66
ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2004.06.004