Essential oil of Lindera neesiana fruit: Chemical analysis and its potential use in topical applications

• Published in: Fitoterapia Vol. 81; no. 1; pp. 11 - 16
• Main Authors: Comai, Stefano, Dall'Acqua, Stefano, Grillo, Alessia, Castagliuolo, Ignazio, Gurung, Khilendra, Innocenti, Gabbriella
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 2010
• Subjects: Anti-Infective Agents, Local - chemistry; Anti-Infective Agents, Local - isolation & purification; Antimicrobial activity; Candida albicans; Cells, Cultured; Essential oil of fruit; Fruit - chemistry; GC-MS; Humans; Keratinocytes - drug effects; Lauraceae; Lindera; Lindera - chemistry; Lindera neesiana; Microbial Sensitivity Tests; Molecular Structure; NMR; Oils, Volatile - chemistry; Oils, Volatile - isolation & purification; Oils, Volatile - toxicity; Plant Extracts - chemistry; Plant Extracts - toxicity; Staphylococcus aureus; GC-MS; Lindera neesiana; NMR; Antimicrobial activity; Essential oil of fruit; Lauraceae
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2009.06.017

The composition of the essential oil of Lindera neesiana Kurz fruit was examined by GC-MS, 1H, 13C and bidimensional NMR techniques (HMQC, HMBC, COSY, TOCSY). Forty compounds were identified, representing approximately 86% of the oil: Z-citral (15.08%), E-citral (11.89%), eucalyptol (8.75%), citronellal (6.72%), α-pinene (6.63%) and β-pinene (5.61%) were the major components. The essential oil of L. neesiana fruit showed significant antimicrobial activity against Staphylococcus aureus and Candida albicans at non-cytotoxic doses in human keratinocytes, suggesting possible topical applications. The essential oil of Lindera neesiana was investigated by GC-MS and NMR techniques. Its biological activities suggest possible topical applications. [Display omitted]