Protection of hepatic cell damage and antimicrobial evaluation of chitosan-catechin conjugate

The chitosan-catechin conjugate was developed by free radical-induced conjugating reaction, and its protection ability against hydrogen peroxide-induced hepatic damage in human normal Chang liver cells and antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and foodborn...

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Published inApplied biological chemistry Vol. 56; no. 6; pp. 701 - 707
Main Authors Cho, Young-Sook, Lee, Dae-Sung, Kim, Young-Mog, Ahn, Chang-Bum, Kim, Do-Hyung, Jung, Won-Kyo, Je, Jae-Young
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.12.2013
Springer Nature B.V
한국응용생명화학회
Subjects
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Applied Microbiology
Biological Techniques
Bioorganic Chemistry
Catechin
Cell viability
Chemistry
Chemistry and Materials Science
Chitosan
Conjugates
Damage assessment
Drug resistance
Foodborne pathogens
Free radicals
Glutathione
Hepatocytes
Hydrogen peroxide
Lipid peroxidation
Lipids
Liver
Methicillin
Original Article
Oxidative stress
Pathogens
Peroxidation
Reactive oxygen species
Staphylococcus aureus
Staphylococcus infections
농학
Antimicrobial
Oxidative stress
Catechin
Chitosan
Antioxidant
Hepatotoxicity
Online AccessGet full text
ISSN1738-2203
2468-0834
2234-344X
2468-0842
DOI10.1007/s13765-013-3168-8

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Abstract The chitosan-catechin conjugate was developed by free radical-induced conjugating reaction, and its protection ability against hydrogen peroxide-induced hepatic damage in human normal Chang liver cells and antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and foodborne pathogens were investigated. Treatment of hydrogen peroxide (650 μM) on Chang liver cells decreased cell viability up to 59.38% compared to the non-treatment group; however, cotreatment of the chitosan-catechin conjugate increased cell viability up to 76.90% at 200 μg/mL, and the protection ability was significantly higher than the unmodified chitosan ( p <0.05). The chitosan-catechin conjugate significantly ( p <0.05) inhibited the formation of intracellular reactive oxygen species and lipid peroxidation in Chang liver cells. Moreover, the chitosan-catechin conjugate increased glutathione levels in normal condition as well as under oxidative stress by hydrogen peroxide. Additionally, the chitosan-catechin conjugate showed increased antimicrobial activity against MRSA and foodborne pathogens as compared to those of the unmodified chitosan.
AbstractList The chitosan-catechin conjugate was developed by free radical-induced conjugating reaction, and its protection ability against hydrogen peroxide-induced hepatic damage in human normal Chang liver cells and antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and foodborne pathogens were investigated. Treatment of hydrogen peroxide (650 μM) on Chang liver cells decreased cell viability up to 59.38% compared to the non-treatment group; however, cotreatment of the chitosan-catechin conjugate increased cell viability up to 76.90% at 200 μg/mL, and the protection ability was significantly higher than the unmodified chitosan ( p <0.05). The chitosan-catechin conjugate significantly ( p <0.05) inhibited the formation of intracellular reactive oxygen species and lipid peroxidation in Chang liver cells. Moreover, the chitosan-catechin conjugate increased glutathione levels in normal condition as well as under oxidative stress by hydrogen peroxide. Additionally, the chitosan-catechin conjugate showed increased antimicrobial activity against MRSA and foodborne pathogens as compared to those of the unmodified chitosan.
The chitosan-catechin conjugate was developed by free radical-induced conjugating reaction, and its protection ability against hydrogen peroxide-induced hepatic damage in human normal Chang liver cells and antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and foodborne pathogens were investigated. Treatment of hydrogen peroxide (650 μM) on Chang liver cells decreased cell viability up to 59.38% compared to the non-treatment group; however, cotreatment of the chitosan-catechin conjugate increased cell viability up to 76.90% at 200 μg/mL, and the protection ability was significantly higher than the unmodified chitosan (p <0.05). The chitosan-catechin conjugate significantly (p <0.05) inhibited the formation of intracellular reactive oxygen species and lipid peroxidation in Chang liver cells. Moreover, the chitosan-catechin conjugate increased glutathione levels in normal condition as well as under oxidative stress by hydrogen peroxide. Additionally, the chitosan-catechin conjugate showed increased antimicrobial activity against MRSA and foodborne pathogens as compared to those of the unmodified chitosan.
The chitosan-catechin conjugate was developed by free radical-induced conjugating reaction, and its protection ability against hydrogen peroxide-induced hepatic damage in human normal Chang liver cells and antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and foodborne pathogens were investigated. Treatment of hydrogen peroxide (650 μM) on Chang liver cells decreased cell viability up to 59.38% compared to the non-treatment group; however, cotreatment of the chitosan-catechin conjugate increased cell viability up to 76.90% at 200 μg/mL, and the protection ability was significantly higher than the unmodified chitosan (p <0.05). The chitosan-catechin conjugate significantly (p <0.05) inhibited the formation of intracellular reactive oxygen species and lipid peroxidation in Chang liver cells. Moreover, the chitosan-catechin conjugate increased glutathione levels in normal condition as well as under oxidative stress by hydrogen peroxide. Additionally, the chitosan-catechin conjugate showed increased antimicrobial activity against MRSA and foodborne pathogens as compared to those of the unmodified chitosan. KCI Citation Count: 4
Author Kim, Do-Hyung
Jung, Won-Kyo
Ahn, Chang-Bum
Kim, Young-Mog
Lee, Dae-Sung
Je, Jae-Young
Cho, Young-Sook
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  fullname: Cho, Young-Sook
  organization: Department of Marine Bio-Food Sciences, Chonnam National University
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  organization: POSTECH Ocean Science and Technology Institute, POSTECH
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  givenname: Young-Mog
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  organization: Department of Food Science and Technology, Pukyong National University
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  surname: Ahn
  fullname: Ahn, Chang-Bum
  organization: Division of Food and Nutrition, Chonnam National University
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  givenname: Do-Hyung
  surname: Kim
  fullname: Kim, Do-Hyung
  organization: Department of Aquatic Life Medicine, Pukyong National University
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  givenname: Won-Kyo
  surname: Jung
  fullname: Jung, Won-Kyo
  email: wkjung@pknu.ac.kr
  organization: Department of Biomedical Engineering, Center for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong National University
– sequence: 7
  givenname: Jae-Young
  surname: Je
  fullname: Je, Jae-Young
  email: jjy1915@jnu.ac.kr
  organization: Department of Marine Bio-Food Sciences, Chonnam National University
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Snippet The chitosan-catechin conjugate was developed by free radical-induced conjugating reaction, and its protection ability against hydrogen peroxide-induced...
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SubjectTerms Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Applied Microbiology
Biological Techniques
Bioorganic Chemistry
Catechin
Cell viability
Chemistry
Chemistry and Materials Science
Chitosan
Conjugates
Damage assessment
Drug resistance
Foodborne pathogens
Free radicals
Glutathione
Hepatocytes
Hydrogen peroxide
Lipid peroxidation
Lipids
Liver
Methicillin
Original Article
Oxidative stress
Pathogens
Peroxidation
Reactive oxygen species
Staphylococcus aureus
Staphylococcus infections
농학
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Title Protection of hepatic cell damage and antimicrobial evaluation of chitosan-catechin conjugate
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