In vitro amoebicidal activity of borage (Borago officinalis) extract on Entamoeba histolytica

Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC₅₀) of the extract for Entamoeba histolytic...

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Bibliographic Details
Published inJournal of medicinal food Vol. 14; no. 7-8; p. 866
Main Authors Leos-Rivas, Catalina, Verde-Star, M Julia, Torres, Lidia Osuna, Oranday-Cardenas, Azucena, Rivas-Morales, Catalina, Barron-Gonzalez, M Porfiria, Morales-Vallarta, Mario R, Cruz-Vega, Delia E
Format Journal Article
LanguageEnglish
Published United States 01.07.2011
Subjects
Amebicides - pharmacology
Amebicides - toxicity
Animals
Artemia - drug effects
Borago - chemistry
Cercopithecus aethiops
Entamoeba histolytica - drug effects
Inhibitory Concentration 50
Lethal Dose 50
Plant Extracts - pharmacology
Plant Extracts - toxicity
Vero Cells
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Summary:Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC₅₀) of the extract for Entamoeba histolytica was 33 μg/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 μg/mL. The IC₅₀ of the extract for Vero cells was 203.9 μg/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.
ISSN:1557-7600
DOI:10.1089/jmf.2010.0164