Microcirculatory alterations in shock states

Functional components of the microcirculation provide oxygen and nutrients and remove waste products from the tissue beds of the body's organs. Shock states overwhelmingly stress functional capacity of the microcirculation, resulting in microcirculatory failure. In septic shock, inflammatory me...

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Bibliographic Details
Published inCritical care nursing clinics of North America Vol. 26; no. 3; p. 399
Main Authors Hamlin, Shannan K, Parmley, C Lee, Hanneman, Sandra K
Format Journal Article
LanguageEnglish
Published United States 01.09.2014
Subjects
Blood Pressure
Cardiac Output
Hemodynamics - physiology
Humans
Microcirculation - physiology
Oxygen - blood
Oxygen Consumption - physiology
Shock, Cardiogenic - therapy
Shock, Septic - physiopathology
Microcirculation
Oxygen extraction
Cardiogenic shock
Septic shock
Oxygen utilization
Oxygen transport
Hypovolemic shock
Blood flow
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Summary:Functional components of the microcirculation provide oxygen and nutrients and remove waste products from the tissue beds of the body's organs. Shock states overwhelmingly stress functional capacity of the microcirculation, resulting in microcirculatory failure. In septic shock, inflammatory mediators contribute to hemodynamic instability. In nonseptic shock states, the microcirculation is better able to compensate for alterations in vascular resistance, cardiac output, and blood pressure. Therefore, global hemodynamic and oxygen delivery parameters are appropriate for assessing, monitoring, and guiding therapy in hypovolemic and cardiogenic shock but, alone, are inadequate for septic shock.
ISSN:1558-3481
DOI:10.1016/j.ccell.2014.04.007