Tucson children's respiratory study: 1980 to present

• Published in: Journal of allergy and clinical immunology Vol. 111; no. 4; pp. 661 - 675
• Main Authors: Taussig, Lynn M., Wright, Anne L., Holberg, Catharine J., Halonen, Marilyn, Morgan, Wayne J., Martinez, Fernando D.
• Format: Book Review Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.04.2003; Elsevier; Elsevier Limited
• Subjects: Acute Disease; Age; Allergic diseases; Asthma; Asthma - etiology; Biological and medical sciences; Child, Preschool; Chronic Disease; Families & family life; Female; Humans; Immunopathology; Infant; Infant, Newborn; Longitudinal Studies; Lung diseases; Male; Medical sciences; Nurses; Pediatrics; Questionnaires; Respiratory and ent allergic diseases; Respiratory diseases; Respiratory Sounds - etiology; Respiratory Tract Diseases - etiology; Respiratory Tract Diseases - immunology; Respiratory Tract Diseases - physiopathology; Risk Factors; Socioeconomic Factors; Studies; Human; Immunopathology; Allergy; risk factors; wheezing syndromes; Respiratory disease; Wheezing; lower respiratory tract illnesses; Asthma; Atopy; Tucson Children's Respiratory Study; lung function; Follow up study; Immunotherapy; Risk factor; Genetics; Obstructive pulmonary disease; immunology
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1067/mai.2003.162

The Tucson Children's Respiratory Study (TCRS), begun in 1980, has followed 1246 subjects from birth together with their family members to delineate the complex interrelationships between a large number of potential risk factors, acute lower respiratory tract illnesses, and chronic lung disorders later in childhood and early adult life, especially asthma. Nine hundred seventy-four (78%) of the original subjects are still being followed. Among its numerous findings, the TCRS has (1) described various wheezing disorders (transient, nonatopic, atopic) and their characteristics; (2) developed an Asthma Predictive Index; (3) delineated the respiratory and atopic outcomes for children who had respiratory syncytial virus–related wheezing illnesses in infancy; and (4) evaluated a large number of risk factors for acute respiratory tract illnesses during the first 3 years of life. Future TCRS studies will focus on (1) factors in infancy and early childhood that relate to persistent asthma and atopy; (2) role of genetic factors in persistent asthma; and (3) determinants of lung function decline in early adult life. (J Allergy Clin Immunol 2003;111:661-75.)