Decursin from Angelica gigas Nakai Blocks hKv1.5 Channel

Decursin was purified from Angelica gigas Nakai, and its effects on the human Kv1.5 (hKv1.5) currents were recorded in mouse fibroblasts (Ltk- cells) by whole-cell patch-clamp technique. Decursin inhibited hKv1.5 current in a concentration-dependent manner, with an IC50 value of 2.7 uM at +60 mV. De...

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Bibliographic Details
Published inBiomolecules & therapeutics Vol. 19; no. 1; pp. 33 - 37
Main Authors Kwak, Yong-Geun, Choi, Bok-Hee, Kim, Dae-Keun, Eun, Jae-Soon
Format Journal Article
LanguageEnglish
Korean
Published 한국응용약물학회 31.01.2011
Subjects
Angelica gigas Nakai
Decursin
hKv1.5 channel blocker
약학
5 channel blocker
Decursin
Angelica gigas Nakai
hKv1
Online AccessGet full text
ISSN1976-9148
2005-4483
DOI10.4062/biomolther.2011.19.1.033

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Summary:Decursin was purified from Angelica gigas Nakai, and its effects on the human Kv1.5 (hKv1.5) currents were recorded in mouse fibroblasts (Ltk- cells) by whole-cell patch-clamp technique. Decursin inhibited hKv1.5 current in a concentration-dependent manner, with an IC50 value of 2.7 uM at +60 mV. Decursin accelerated the inactivation kinetics of the hKv1.5 channel, and slowed the deactivation kinetics of the hKv1.5 current, resulting in a tail crossover phenomenon. Also, decursin inhibited the hKv1.5 current in a use-dependent manner. These results strongly suggest that decursin is a kind of open-channel blocker of the hKv1.5 channel.
Bibliography:The Korean Society of Applied Pharmacology
KISTI1.1003/JNL.JAKO201108863884185
G704-000363.2011.19.1.001
ISSN:1976-9148
2005-4483
DOI:10.4062/biomolther.2011.19.1.033