Humoral immune responses to adenovirus vectors in the brain

• Published in: Journal of neuroimmunology Vol. 103; no. 1; pp. 8 - 15
• Main Authors: Kajiwara, Koji, Byrnes, Andrew P, Ohmoto, Yoshinori, Charlton, Harry M, Wood, Matthew J.A, Wood, Kathryn J
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2000
• Subjects: Adenoviridae - genetics; Adenoviridae - immunology; Adenovirus; Adenovirus vectors; Animals; Antibodies, Viral - biosynthesis; Antibody; beta-Galactosidase - immunology; Brain; Brain - immunology; Gene transfer; Genetic Therapy; Genetic Vectors; Immune response; Immunohistochemistry; lacZ gene; Male; Mice; Mice, Inbred C3H; β-Galactosidase; Brain; Adenovirus vectors; Immune response; Gene transfer; Antibody; β-Galactosidase

We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibod...