Humoral immune responses to adenovirus vectors in the brain

We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibod...

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Published inJournal of neuroimmunology Vol. 103; no. 1; pp. 8 - 15
Main Authors Kajiwara, Koji, Byrnes, Andrew P, Ohmoto, Yoshinori, Charlton, Harry M, Wood, Matthew J.A, Wood, Kathryn J
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2000
Subjects
Adenoviridae - genetics
Adenoviridae - immunology
Adenovirus
Adenovirus vectors
Animals
Antibodies, Viral - biosynthesis
Antibody
beta-Galactosidase - immunology
Brain
Brain - immunology
Gene transfer
Genetic Therapy
Genetic Vectors
Immune response
Immunohistochemistry
lacZ gene
Male
Mice
Mice, Inbred C3H
β-Galactosidase
Brain
Adenovirus vectors
Immune response
Gene transfer
Antibody
β-Galactosidase
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Abstract We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibody production to β-galactosidase, the product of the lacZ gene, was detected later than anti-adenovirus antibody. Neutralizing antibody was not detected. This study demonstrates that E1-deleted adenovirus vectors injected into the brain trigger humoral immune responses to the adenovirus and its gene products, but they are not sufficient to block the infection of cells by adenovirus upon repeat injection.
AbstractList We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibody production to beta -galactosidase, the product of the lacZ gene, was detected later than anti-adenovirus antibody. Neutralizing antibody was not detected. This study demonstrates that E1-deleted adenovirus vectors injected into the brain trigger humoral immune responses to the adenovirus and its gene products, but they are not sufficient to block the infection of cells by adenovirus upon repeat injection.
We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibody production to β-galactosidase, the product of the lacZ gene, was detected later than anti-adenovirus antibody. Neutralizing antibody was not detected. This study demonstrates that E1-deleted adenovirus vectors injected into the brain trigger humoral immune responses to the adenovirus and its gene products, but they are not sufficient to block the infection of cells by adenovirus upon repeat injection.
Author Wood, Kathryn J
Charlton, Harry M
Wood, Matthew J.A
Kajiwara, Koji
Byrnes, Andrew P
Ohmoto, Yoshinori
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  givenname: Kathryn J
  surname: Wood
  fullname: Wood, Kathryn J
  organization: Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
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Issue 1
Keywords Brain
Adenovirus vectors
Immune response
Gene transfer
Antibody
β-Galactosidase
Language English
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SSID ssj0015349
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Snippet We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these...
We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these...
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pubmed
elsevier
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SubjectTerms Adenoviridae - genetics
Adenoviridae - immunology
Adenovirus
Adenovirus vectors
Animals
Antibodies, Viral - biosynthesis
Antibody
beta-Galactosidase - immunology
Brain
Brain - immunology
Gene transfer
Genetic Therapy
Genetic Vectors
Immune response
Immunohistochemistry
lacZ gene
Male
Mice
Mice, Inbred C3H
β-Galactosidase
Title Humoral immune responses to adenovirus vectors in the brain
URI https://dx.doi.org/10.1016/S0165-5728(99)00220-9
https://www.ncbi.nlm.nih.gov/pubmed/10674984
https://search.proquest.com/docview/17446224
https://search.proquest.com/docview/70908421
Volume 103
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