Mitochondrial DNA Leakage Caused by Streptococcus pneumoniae Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells
, the bacterial pathogen responsible for invasive pneumococcal diseases, is capable of producing substantial amounts of hydrogen peroxide. However, the impact of -secreted hydrogen peroxide (H O ) on the host immune processes is not completely understood. Here, we demonstrated that -secreted H O cau...
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Published in | Frontiers in microbiology Vol. 10; p. 630 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
28.03.2019
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Subjects | |
Online Access | Get full text |
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Summary: | , the bacterial pathogen responsible for invasive pneumococcal diseases, is capable of producing substantial amounts of hydrogen peroxide. However, the impact of
-secreted hydrogen peroxide (H
O
) on the host immune processes is not completely understood. Here, we demonstrated that
-secreted H
O
caused mitochondrial damage and severe histopathological damage in mouse lung tissue. Additionally,
-secreted H
O
caused not only oxidative damage to mitochondrial deoxyribonucleic acid (mtDNA), but also a reduction in the mtDNA content in alveolar epithelia cells. This resulted in the release of mtDNA into the cytoplasm, which subsequently induced type I interferons (IFN-I) expression. We also determined that stimulator of interferon genes (STING) signaling was probably involved in
H
O
-inducing IFN-I expression in response to mtDNA damaged by
-secreted H
O
. In conclusion, our study demonstrated that H
O
produced by
resulted in mtDNA leakage from damaged mitochondria and IFN-I production in alveolar epithelia cells, and STING may be required in this process, and this is a novel mitochondrial damage mechanism by which
potentiates the IFN-I cascade in
infection. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology Edited by: Fernanda Cristina Petersen, University of Oslo, Norway Reviewed by: Dane Parker, New Jersey Medical School, United States; Jessica Lynn Humann, Florida A&M University, United States These authors have contributed equally to this work as first authors |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2019.00630 |