Eosinophilic chronic rhinosinusitis in East Asians

Chronic rhinosinusitis (CRS) is a common disease worldwide, with a prevalence rate of 5%-15% in the general population. CRS is currently classified into two types: CRS with and without nasal polyps. CRS may also be divided into eosinophilic CRS (ECRS) and non-ECRS subtypes based on the presence of t...

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Published inWorld journal of clinical cases Vol. 2; no. 12; pp. 873 - 882
Main Authors Wang, En-Tong, Zheng, Yan, Liu, Peng-Fei, Guo, Li-Juan
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 16.12.2014
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Summary:Chronic rhinosinusitis (CRS) is a common disease worldwide, with a prevalence rate of 5%-15% in the general population. CRS is currently classified into two types: CRS with and without nasal polyps. CRS may also be divided into eosinophilic CRS (ECRS) and non-ECRS subtypes based on the presence of tissue eosinophilic infiltration or not. There are significant geographic and ethnic differences in the tissue eosinophilic infiltration, which is predominant in Western white patients and less common in East Asians, despite an increasing tendency for its prevalence in East Asia countries. ECRS differs significantly from non-ECRS in clinical characteristics, treatment outcomes and strategies, and underlying pathogenic mechanisms. ECRS commonly demonstrates more severe symptoms, polyp diseases with a higher incidence of bilateral polyps and sinonasal diseases on computed tomography, and the increase in blood eosinophils. ECRS is considered a special and recalcitrant subtype of CRS, commonly with poor treatment outcomes compared to non-ECRS. The differentiation of specific subtypes and clinical features of CRS will be important for developing novel treatment strategies and improving treatment outcomes for individual phenotypes of CRS. This review discusses clinical features, diagnosis, treatment and prognosis of ECRS in East Asians.
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Correspondence to: En-Tong Wang, MD, PhD, Department of Otolaryngology, Head and Neck Surgery, Air Force General Hospital, 30 Fucheng Road, Beijing 100142, China. wang_entong@sina.com
Author contributions: Wang ET contributed to the study design and wrote the review; Zheng Y, Liu PF and Guo LJ were involved in the acquisition, analysis and interpretation of data.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v2.i12.873