MATP polymorphisms in Germans and Japanese: the L374F mutation as a population marker for Caucasoids

Inference of the population and ancestry to which an individual belongs is important in forensic individualization and personal identification. In this study, five polymorphisms of the membrane-associated transporter protein (MATP) gene were investigated in German and Japanese populations. The L374F...

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Published inInternational journal of legal medicine Vol. 118; no. 6; pp. 364 - 366
Main Authors Yuasa, Isao, Umetsu, Kazuo, Watanabe, Gotaro, Nakamura, Hiroaki, Endoh, Minoru, Irizawa, Yoshito
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.12.2004
Subjects
Antigens, Neoplasm
DNA Fingerprinting
European Continental Ancestry Group - genetics
Gene Frequency
Genetic Markers
Germany
Haplotypes - genetics
Humans
Japan
Membrane Proteins - genetics
Membrane Transport Proteins
Polymorphism, Genetic
Japan
Germany
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Summary:Inference of the population and ancestry to which an individual belongs is important in forensic individualization and personal identification. In this study, five polymorphisms of the membrane-associated transporter protein (MATP) gene were investigated in German and Japanese populations. The L374F mutation was present at an allele frequency as high as 0.96 in the German population, whereas it was completely absent in the Japanese population. This extreme difference in allele frequency suggests that the L374F mutation is valuable as a population and ancestry informative marker for Caucasoids.
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ISSN:0937-9827
1437-1596
DOI:10.1007/s00414-004-0490-z