Antifungal of modified neolignans from Mitrephora wangii Hu

Chromatographic separation of leaves and twigs from M. wangii had led to the isolation of conocarpan ( 1 ) and 3′-methoxyconocarpan ( 2 ). These structures were assigned on the basis of spectroscopic methods. Compound 1 was modified by organic reactions and the modified compound 5 exhibited potent a...

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Published inApplied biological chemistry Vol. 59; no. 3; pp. 385 - 389
Main Authors Sanyacharernkul, Saksri, Nantapap, Sirinapa, Sangrueng, Kallaya, Nuntasaen, Narong, Pompimon, Wilart, Meepowpan, Puttinan
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.06.2016
Springer Nature B.V
한국응용생명화학회
Subjects
Applied Microbiology
Biological Techniques
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Food poisoning
Fungi
Fungicides
Mancozeb
Mycelia
Toxicity
농학
Neolignans
Conocarpan
Annonaceae
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Summary:Chromatographic separation of leaves and twigs from M. wangii had led to the isolation of conocarpan ( 1 ) and 3′-methoxyconocarpan ( 2 ). These structures were assigned on the basis of spectroscopic methods. Compound 1 was modified by organic reactions and the modified compound 5 exhibited potent antifungal, Pyricularia oryzae . The method used poisoned food technique with mycelial growth inhibition for 14 days, 57 % (100 ppm). Compound 5 was stronger than mancozeb which the fungi toxicity drug used as a positive control.
Bibliography:G704-000111.2016.59.3.019
ISSN:2468-0834
2468-0842
DOI:10.1007/s13765-016-0178-3