5-HT1A receptor ligands and their therapeutic applications: review of new patents

5-HT R was one of the first discovered serotonin receptors and is one of the most thoroughly studied. Dysfunctions associated with 5-HT R neurotransmission are linked to several psychiatric disorders, including anxiety, depression, and movement disorders. The current review covers patent literature...

Full description

Saved in:
Bibliographic Details
Published inExpert opinion on therapeutic patents Vol. 28; no. 9; p. 679
Main Authors Staroń, Jakub, Bugno, Ryszard, Hogendorf, Adam S, Bojarski, Andrzej J
Format Journal Article
LanguageEnglish
Published England 02.09.2018
Subjects
Animals
Drug Design
Humans
Ligands
Patents as Topic
Receptor, Serotonin, 5-HT1A - drug effects
Receptor, Serotonin, 5-HT1A - metabolism
Serotonin 5-HT1 Receptor Agonists - pharmacology
Serotonin 5-HT1 Receptor Antagonists - pharmacology
5-HT1A
serotonin receptor
serotonin modulator
agonist
antagonist
therapeutic patent
Online AccessGet more information

Cover

More Information
Summary:5-HT R was one of the first discovered serotonin receptors and is one of the most thoroughly studied. Dysfunctions associated with 5-HT R neurotransmission are linked to several psychiatric disorders, including anxiety, depression, and movement disorders. The current review covers patent literature published between January 2012 and May 2018. Queries were performed on Espacenet, SciFinder, clinicaltrials.gov, pharmacodia.com, and the websites of pharmaceutical companies. Several novel therapeutic applications have been proposed for 5-HT R ligands, i.e. prostate cancer treatment, gastrointestinal and cardiopulmonary disorders, facilitation of urination and defecation, and L-DOPA-induced dyskinesia. Interestingly, no patent application has been filed by big pharma companies, while numerous researches are being conducted in smaller companies and academia.
ISSN:1744-7674
DOI:10.1080/13543776.2018.1514011