Gastro‑intestinal dysfunctions in Parkinson's disease (Review)

In patients with Parkinson's disease (PD), gastrointestinal dysfunction occurs from the early stages of the disease and even in the pre-motor phase. This condition can include the entire digestive tract, with symptoms ranging from delays in gastric emptying to dysphagia, constipation and even m...

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Published inExperimental and therapeutic medicine Vol. 22; no. 4
Main Authors Ivan, Irina-Florina, Irincu, Valentina-Laura, Diaconu, Stefania, Falup-Pecurariu, Oana, Ciopleias, Bogdan, Falup- Pecurariu, Cristian
Format Journal Article
LanguageEnglish
Published Athens Spandidos Publications 01.10.2021
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects
Appetite
Body mass index
Causes of
Complications and side effects
Constipation
Defecation
Deglutition disorders
Dementia
Development and progression
Dyskinesia
Dysphagia
Educational aspects
Fecal incontinence
Gastrointestinal diseases
Helicobacter infections
Infections
Malnutrition
Motility
Osteoporosis
Parkinson's disease
Pathogenesis
Patients
Pharmacokinetics
Pneumonia
Quality of life
Review
Risk factors
Vitamin deficiency
Romania
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Summary:In patients with Parkinson's disease (PD), gastrointestinal dysfunction occurs from the early stages of the disease and even in the pre-motor phase. This condition can include the entire digestive tract, with symptoms ranging from delays in gastric emptying to dysphagia, constipation and even malnutrition. Excess saliva accumulates in the mouth due to the low frequency of swallowing. Dysphagia develops in about 50% of patients and may be a reflection of both central nervous system and enteric nervous system disorder. Gastroparesis can cause a variety of symptoms, including nausea, and also may be responsible for some of the motor fluctuations observed with levodopa therapy. Intestinal dysfunction in PD may be the result of both delayed colon transit and impaired anorectal muscle coordination. In addition, recent studies have demonstrated the role of Helicobacter pylori infection in the pathogenesis of diseases but also the occurrence of motor fluctuations by affecting the absorption of anti-parkinsonian medication. In this review, the main gastrointestinal dysfunctions associated with PD are presented.
Bibliography:Contributed equally
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.10517